Have the Republicans already lost?

At the moment, the polls are in Obama's favor. However, there are still 3 weeks remaining before the election which in politics is an eon. Anything can happen to sway voters' opinions. At this point, the right-win conservative columnists, like David Brooks/Bill Kristol/Kathleen Parker are commenting that Palin was indeed a dangerous and inane selection for VP nominee. Christopher Buckley (William F.'s son) recently left his position at his late father's magazine, The National Review, due to his support of Obama. Kristol has even advised (via his column in the New York Times) McCain to fire his entire campaign staff and start over. This is definitely not an optimistic sign for the GOP.